Details

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Piperacillin 4g + Tazobactam 0.5g Injection is an antibiotic belonging to the Extended-spectrum penicillins group in beta lactams category.

It is also known as an antipseudomonal penicillin as it is effective in Pseudomonas aeruginosa.

It is a combination drug piperacillin is only available with β-lactamase inhibitor tazobactam. Tazobactam is required to extend the activity of piperacillin against β-lactamase-producing strains of S aureus and Gram-negative bacteria.

It is used clinically inStreptococcal, meningococcal and neurosyphilis infections.

Mechanism of action:It acts by preventing bacterial cell wall synthesis by binding and inhibiting cell wall transpeptidases leading to death of the bacterial cell.

It is available as Tazocin&Zosyn  in both International and Zosyn Indian markets.

 

Uses

• Piperacillin 4g + Tazobactam 0.5g Injection is used in Intra-abdominal caused by Bacteroides fragilis and  Escherichia coli
• It is used in Female pelvic infections caused by Escherichia coli .
• Zosyn is used in skin infections and diabetic foot caused by Staphylococcus aureus.
• Tazocin is also prescribed in Community-acquired pneumonia caused by Haemophilusinfluenzae and Nosocomial pneumonia caused by Staphylococcus aureus,Haemophilus influenzae, Klebsiella pneumoniae and Pseudomonas aeruginosa.

 

Dosage

• Piperacillin 4g + Tazobactam 0.5g Injection comes as white to off-white powder in vials for reconstitution with the solvents and is further diluted with solutions as per instructions.
• It is given as intravenous infusion over 30 minutes or intramuscularly.
• The usual daily dose of Zosyn for adults is 12.0 g piperacillin/1.5 g tazobactam divided in 6 hours.
• Final dosages are determined by the doctor on the basis of factors such as pre existing medical condition, severity of infection, age, weight and ongoing medications.
• Dose and rate of infusion is adjusted to minimise related side effects.

 

Side effects

• Headache
• Fever
• Fatigue
• Hypersensitivity
• Nausea and vomiting
• Skin rashes
• Oral lesions
• Interstitial nephritis
• Eosinophilia
• Hemolytic anemia
• Vasculitis
• Seizures in renal patients
• Acute kidney injury
• Clostridium difficile associated diarrhea
• Hypoglycemia
• Insomnia
• Abdominal pain
• Decreased coagulation

 

Precautions

• Piperacillin 4g + Tazobactam 0.5g Injection is contraindicated in cases of allergy or history of allergic reactions to any of the penicillins, cephalosporins, or β-lactamase inhibitors.
• Patients must be monitored carefully for severe allergic reactions and diarrhea related to antibiotics.
• Regular tests for kidney and blood are necessary.
• Tell the doctor about pre existing medical conditions, ongoing medications and any allergy before starting the drug.

Always tell the doctor about pregnancy or future plan of pregnancy or breastfeeding.