Details

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Teicoplanin 200mg, 400mg Injection is a newly developed glycopeptide antibiotic which kills both aerobic and anaerobic Gram-positive bacteria.

It is mostly used in patients resistant or allergic to penicillin in place of vancomycin.

Mechanism of action:it acts by inhibiting the action of transglycosylase resulting in prevention of elongation of peptidoglycan and crosslinking during cell wall synthesis. This causes the death of the gram positive bacteria due to a weakened cell wall.

It is available as Targocid in both Indian and International markets

 

Uses

• Teicoplanin 200mg, 400mg Injection is used in skin, underskin, bones, joints, blood, lungs, abdominal wall(colitis) and urinary tract infections.
• It is very effective against Clostridium difficile infection causing Pseudomembranous colitis and diarrhea.
• It is given as antimicrobial prophylaxis for surgical site infection.
• It is prescribed if an infected central venous catheter is suspected, to protect from Gram-positive organisms.
• It is also given as prophylaxis in patients who have received recent antibiotic therapy..
• Targocid is also used in gangrenous amputations, enterococcal endocarditis(in combination with gentamicin), penicillin resistant streptococcal infections, pneumococcal meningitis due to Internal shunt infection and MRSA along with other antibiotics

 

Side effects

• Rashes
• Fever and chills
• Granulocytopenia
• Headache
• Dizziness
• nephrotoxicity
• ototoxicity

 

Precautions

• Tell the doctor about any allergy, especially history of vancomycin allergy and medical conditions like red man syndrome and thrombocytopenia or kidney problems, pregnancy, future plan of pregnancy and breastfeeding as it can cause hearing and kidney defects to the foetus.
• Inform the doctor about the ongoing medications like aminoglycosides as they can interact with Targocid and can further increase hearing and kidney problems.
• Teicoplanin 200mg, 400mg Injection has less adverse effects than vancomycin but still regular kidney and liver tests must be done to check for kidneys and liver toxicity.

 

Dosage

• Targocid comes as 200mg , 400mg per vial injection for reconstitution  and administered intravenously intramuscular or infusion into the vein through drip by a healthcare professional.
• Usually it is given – 400mg on the first day then 200mg daily i.v. or i.m. and for severe infections 400mg three times at an interval of 12 hours then 400mg daily.
• Final doses are determined by the doctor on the basis of severity of the infection, weight and other medical conditions.

 

Review

• Teicoplanin 200mg, 400mg Injection is preferred due to its method of administration as it can also be given as bolus i.m. or orally while Vancomycin is given only intravenously for over 2hours.

It is an expensive medicine.