Details

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Basiliximab 20mg Injection is an immunosuppressive agent used as prophylaxis treatment or in combination with other immunosuppressants.

It is a prescription only drug.

It is well tolerated and premedication is not required.

It is a murine/human chimeric monoclonal antibody produced by recombinant DNA technology.

Mechanism of action:it is a chimeric monoclonal antibody that acts by binding to CD25, the InterLeukin-2 receptor α chain present on the surface of the activated T lymphocytes.This binding inhibits T lymphocytes proliferation and decreases or stops the cellular immune response against the transplant.

It is available as Simulect in both International and Indian markets.

Uses

• Basiliximab 20mg Injection is prescribed in acute rejection of the kidney transplant along with glucocorticoids and cyclosporine.
• Simulect is used as prophylaxis in acute kidney, heart and liver transplantation rejection because of its very good response.
• It is also used in treatment of Refractory Acute GVHD.

 

Dosage

• Simulect comes as a 20 mg sterile freeze-dried white powder vial & solvent ampule and reconstituted with solvent (5 ml water) before injection or infusion.
• It is given intravenously either as injection or infusion by the healthcare professionals only.
• Usually Basiliximab 20mg Injection dose given as prophylaxis and treatment is 20mg IV before the surgery followed by 20mb IV for 4 days after transplant in adults.
• In children, it is given as 10mg IV 2 hours before surgery then 10mg IV for 4 days.
• Dosages are determined by the doctor according to the severity of condition, pre existing medical condition, weight, response and side effects of the body to the drug.
• Dosages are also adjusted according to the dose related side effects
• It is stored at 2°C – 8°C temperature in the refrigerator and a reconstituted solution can be stored for 24 hours at 2°C – 8°C or for 4 hours at room temperature.

 

Side effects

• Fever and chills
• Nausea and vomiting
• Constipation
• Hypersensitivity reaction like rashes, urticaria, respiratory distress
• Pain
• Anemia
• Hypertension
• Peripheral oedema
• High cholesterol level
• Headache
• Dizziness
• Infections or respiratory and urinary tract due to immunosuppression
• Lymphoproliferative disorders

 

Precautions

• Basiliximab 20mg Injection is not recommended in pregnancy and breastfeeding mothers.
• Careful monitoring and follow ups are necessary by healthcare professionals to avoid hypersensitive reaction, infections and lymphoproliferative malfunctions..
• Tell the doctor about ongoing medications and any allergy before starting the drug.
• Always tell the doctor about pregnancy or future plan of pregnancy or breastfeeding.

Simulect is contraindicated in hypersensitivity reaction to Basiliximab.