Details

---

Haloperidol 5mg injection is an antipsychotic drug belonging to the Butyrophenone derivatives group.

It is the most widely used first generation antipsychotic drug or conventional antipsychotic drug.

It is a prescription only drug.

It is a long acting injection (LAI) antipsychotic.

It is mostly used in the cases when a patient is not able to take oral form of haloperidol.

Mechanism of action:it acts by tightly binding to dopaminergic neuroreceptors leading to competitively blocking of dopamine D2 receptors resulting in antipsychotic effects.

It is available as Haldol & Serenase in International and as Serenace in Indian markets.

 

Uses

• Haloperidol 5mg injection is used in treating positive symptoms of schizophrenia especially in older patients.
• Haldol is used in the treatment of drug-induced nausea.
• Serenase is used in the treatment of the motor and phonic tics of Tourette disorder.
• Serenace is used to induce sedation of agitated patients and in children with aggressive behaviour due to mental disorders.
• It is also used in geriatric patients for the treatment of symptoms of delirium, dementia, agitation, and paranoid syndrome.

 

Dosage

• Haloperidol 5mg injection comes as a clear ,colourless, sterile solution in single use ampoules and is given intramuscularly only by healthcare professionals.
• Serenace must be stored at the temperature below 25°C away from the light in its original container.
• Final doses are determined by the doctor on the basis of pre existing medical condition, ongoing medications, age, weight and any allergy.
• Doses are also modified according to dose related side effects..

 

Side effects

• Headache
• Weakness
• Loss of appetite
• Indigestion
• Constipation
• Hypotension
• Weight gain
• Sedation
• Depression
• extrapyramidal symptoms
• Muscle wasting
• Parkinsonism
• Blurred vision
• Dry mouth
• Muscular rigidity
• hot flashes
• Ovarian enlargement
• Prolonged QT interval
• Urinary retention
• Decreased Gastrointestinal motility
• neuroleptic malignant syndrome
• Dementia
• Hyperprolactinemia

 

Precautions

• Haloperidol 5mg injection is contraindicated in case of allergy to haloperidol severe CNS depression,seizure disorder and parkinsonism.
• Older patients having symptoms of dementia are at increased risk of death due to cardiac failure and infections like pneumonia.
• It interacts with a large number of other drugs like drugs used for bipolar disorder, blood pressure lowering drugs,anticoagulants, drugs used to treat parkinsonism, anti seizure drugs and antibiotics.
• Close monitoring is required for mental status change, hypotension, muscle rigidity, autonomic instability and neuroleptic malignant syndrome.
• Always tell the doctor about pre-existing medical conditions, ongoing medications, any history of allergic reaction, pregnancy, future plan of pregnancy and pregnancy.
• Serenace is not recommended for use in pregnancy and breastfeeding mothers.

Driving and use of machines must be avoided while taking haloperidol.