Details

---

Infliximab 100mg Injection is an immunosuppressant agent that belongs to the TNFalpha blockers group.

It is a chimeric (25% mouse, 75% human) IgG1 monoclonal antibody.

Its efficacy reduces after formation of anti Infliximab antibodies in the body, so it is not recommended for monotherapy.

Mechanism of action:It acts by binding to specifically  soluble and membrane bound TNF-α preventing its interaction with p55 and p75 cell surface receptors. This leads to down-regulation of macrophage and T-cell function leading to decreased immunity of the body.

It is available as Remicade in both International and Indian markets.

 

Uses

• Infliximab 100mg Injection is indicated in Crohn’s Disease ,Pediatric Crohn’s Disease, Ulcerative Colitis, Pediatric Ulcerative Colitis, Ankylosing Spondylitis and Plaque Psoriasis Psoriatic Arthritis.
• Remicade is used with methotrexate in the treatment of Rheumatoid Arthritis.
• Other indications of Remicade are granulomatosis with polyangiitis (Wegener’s granulomatosis), giant cell arteritis, Behçet’s disease, uveitis,and sarcoidosis.

 

Dosage

• Infliximab 100mg Injection comes as a vial containing 100 mg lyophilized powder to be reconstituted with20 ml vial before using as injection and further diluted for infusion intravenously.
• Unused portion of the solution must be discarded as it contains no antibacterial preservatives.
• The usual dose of Remicade is 3–5 mg/kg every 8 weeks.
• Final doses are determined by the doctor on the basis of pre existing medical condition , ongoing medications, age, weight and any allergy.
• Doses and infusion rate are also modified according to dose related side effects.

 

Side effects

• Headache
• Fever
• Nausea and vomiting
• Abdominal pain
• Diarrhea
• Allergic reactions
• Flu-like symptoms
• Hypertension
• Upper respiratory tract infections
• Coughing
• Pharyngitis
• Skin rash
• Fatigue
• Arthralgia
• Urinary tract infection
• Bacterial, viral and Invasive fungal infections
• Opportunistic infections
• Reactivation of tuberculosis and hepatitis b virus
• Lymphoma and other malignancies
• Hepatosplenic T-cell lymphoma (HSTCL)
• Lupus and lupus-like syndromes

 

Precautions

• Infliximab 100mg Injection is contraindicated in cases of hypersensitivity to infliximab and moderate to severe heart failure.
• Close monitoring is required for signs and symptoms of serious infections, hepatotoxicity, malignancies, latent tuberculosis , reactivation HBV, heart failure, hematologic, neurologic and allergic reactions during and after treatment.
• The combination of infliximab and anakinra or abatacept or tocilizumab is not recommended because of high risk of serious infections.
• Live vaccines must not be given concurrently with infliximab.
• Always tell the doctor about pre-existing medical conditions, ongoing medications, any history of allergic reaction, pregnancy , future plan of pregnancy and pregnancy.

It must be used in pregnancy and breastfeeding mothers with caution.