Premarin

Drug Name:

Conjugated Estrogens 0.625mg/0.3mg Tablets

Category:

International Brand: Premarin/Enjuvia

Premarin/Enjuvia

Details

Conjugated Estrogens 0.625mg/0.3mg Tablets are Oestrogens and Progesterones agents. It is a hormone replacement therapy consisting of Progesterones and Oestrogens. It reduces the vaginal symptoms of menopause in women such as burning, itching, or dryness. Premarin is the universal brand name of this medicine. However, it is also known by the name Enjuvia abroad.

Purpose:

It is used to treat:

  • Hot flushes
  • Itching in vagina
  • Estrogen deficiency
  • Thinning of bones (Osteoporosis)
  • Breast cancer
  • Prostate cancer

 

Mechanism:

Conjugated Estrogens 0.625mg/0.3mg Tablets replace the lack of estrogen production by the female ovaries that happen during menopause and relieve the mild or severe symptoms of menopause. These can be bones getting porous, mood swings, night sweats among others.

 

Dosage:

  • As prescribed by your doctor/physician.
  • The recommended dosage of Enjuvia for prostate cancer: 625 mg every 1-2 weeks
  • The recommended dosage of this medication for vasomotor symptoms associated with menopause: 0.3mg every 3-4 weeks
  • The recommended dosage of this medication for ovarian failure: 0.3mg every 4 weeks
  • The recommended dosage of this medication for vaginal atrophy in menopause: 0.625mg 4 weeks

 

Side effects:

  • Dry mouth
  • Headache
  • Impotence
  • Vomiting
  • Acne
  • Delayed ejaculation
  • Excessive thirst
  • Melasma
  • Influenza
  • Bloating
  • Stomach cramps
  • Vaginal ulceration
  • Fluctuation of weight
  • Swelling of extremities
  • If you spot any vaginal bleeding, dark urine, pulmonary embolism, deep vein thrombosis, or blood in cough during the tenure of Premarin at any point, consult your doctor right away.

 

Precautions and measures:

  • If you have ever had breast or ovarian cancer, inform your doctor before starting with Premarin tablets.
  • Any case of uterus problems such as endometriosis or fibroids should be reported to the doctor as well.
  • Consumption of tobacco or cigarettes is strictly prohibited during the period.
  • Conjugated Estrogens 0.625mg/0.3mg Tablets can lead to melasma and can worsen if you face the sun. Limit your time under the sun, and be fully clothed when outdoors.
  • The patient might face problems in wearing contact lenses, he/she may consult his/her eye specialist.
  • It has been established that most of the children are intolerant of this drug and therefore it should be given to them under strict guidance.
  • Under no circumstances a pregnant and lactating woman should use this medication.
  • Conjugated Estrogens 0.625mg/0.3mg Tablets should not be used to cure Dementia.
  • If you are going to have major surgery, this medication should be discontinued at least 4 weeks before that.
  • Store it a room temperature between 10°-30°
  • It is not meant for children.

 

Interactions:

  • Aromatase inhibitors such as Letrozole, Anastrozole, and Eexemestane can react negatively with Premarin.

Consuming this medication might interfere with the Metyrapone laboratory test.