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Premarin

Drug Name:

Conjugated Estrogens 25mg Injection

Category:

International Brand: Premarin/Enjuvia

Premarin/Enjuvia

Details

Conjugated Estrogens 25mg Injection is an Oestrogens and Progesterones agent. It is a hormone replacement therapy consisting of Progesterones and Oestrogens. It reduces the vaginal symptoms of menopause in women such as burning, itching, or dryness. Premarin is the universal brand name of this medicine. However, it is also known by the name Enjuvia abroad.

 

Purpose:

Premarin is used to treat:

  • Hot flushes
  • Itching in vagina
  • Estrogen deficiency
  • Thinning of bones (Osteoporosis)
  • Breast cancer
  • Prostate cancer
  • Endometrial cancer

 

Mechanism:

Conjugated Estrogens 25mg Injection replaces the lack of estrogen production by the female ovaries that happen during menopause and relieves the mild or severe symptoms of menopause. These can be bones getting porous, mood swings, night sweats among others.

Dosage:

  • As prescribed by your doctor/physician.
  • The injection is administered intravenously or intramuscularly.
  • The recommended dosage of Enjuvia for prostate cancer: 25mg every 1-2 weeks
  • The recommended dosage of this medication for vasomotor symptoms associated with menopause: 25mg every 3-4 weeks
  • The recommended dosage of this medication for ovarian failure: 25mg every 4 weeks
  • The recommended dosage of this medication for vaginal atrophy in menopause: 12.5mg every 4 weeks

Side effects:

Genitourinary system

  • Abnormal uterine bleeding/spotting.
  • Dysmenorrhea or pelvic pain.
  • Increase in size of uterine leiomyomata.
  • Vaginitis, including vaginal candidiasis.
  • Change in amount of cervical secretion.
  • Change in cervical ectropion.
  • Ovarian cancer.
  • Endometrial hyperplasia.
  • Endometrial cancer.

Breasts

  • Tenderness, enlargement, pain, discharge, galactorrhea.
  • Fibrocystic breast changes.
  • Breast cancer.

Cardiovascular

  • Deep and superficial venous thrombosis.
  • Pulmonary embolism.
  • Thrombophlebitis.
  • Myocardial infarction.
  • Stroke
  • Increase in blood pressure.

Gastrointestinal

  • Nausea, vomiting.
  • Abdominal cramps, bloating.
  • Cholestatic jaundice.
  • Increased incidence of gallbladder disease.
  • Pancreatitis.
  • Enlargement of hepatic hemangiomas.
  • Ischemic colitis.

Skin

  • Chloasma or melasma may persist when the drug is discontinued.
  • Erythema multiforme.
  • Erythema nodosum.
  • Hemorrhagic eruption.
  • Loss of scalp hair.
  • Hirsutism.
  • Pruritis.
  • Rash.

Eyes

  • Retinal vascular thrombosis.
  • Intolerance to contact lenses.

Central Nervous System

  • Headache.
  • Migraine.
  • Dizziness.
  • Mental depression.
  • Exacerbation of chorea.
  • Nervousness.
  • Exacerbation of epilepsy.
  • Dementia.
  • Possible growth potentiation of benign meningioma.

Miscellaneous

  • Increase or decrease in weight.
  • Glucose intolerance.
  • Aggravation of porphyria.
  • Edema.
  • Arthralgia.
  • Leg cramps.
  • Changes in libido.
  • Urticaria.
  • Hypocalcemia (preexisting condition).
  • Injection site pain.
  • Injection site edema.
  • Phlebitis (injection site).
  • Exacerbation of asthma.
  • Increased triglycerides.

 

Precautions and measures:

  • If you have ever had breast or ovarian cancer, inform your doctor before starting with Premarin tablets.
  • Any case of uterus problems such as endometriosis or fibroids should be reported to the doctor as well.
  • Consumption of tobacco or cigarettes is strictly prohibited during the period.
  • Conjugated Estrogens 25mg Injection can lead to melasma and can worsen if you face the sun. Limit your time under the sun, and be fully clothed when outdoors.
  • The patient might face problems in wearing contact lenses, he/she may consult his/her eye specialist.
  • It has been established that most of the children are intolerant of this drug and therefore it should be given to them under strict guidance.
  • Under no circumstances a pregnant and lactating woman should use this medication.
  • Conjugated Estrogens 25mg Injection should not be used to cure Dementia.
  • If you are going to have major surgery, this medication should be discontinued at least 4 weeks before that.
  • Store it a room temperature between 10°-30°
  • It is not meant for children.

 

Interactions:

  • Aromatase inhibitors such as Letrozole, Anastrozole, and Eexemestane can react negatively with Premarin.

Consuming this medication might interfere with the Metyrapone laboratory test.