Phosome

Details

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Liposomal Amphotericin B 10mg, 25mg, 50mg Injection is an Antifungal agent. It is a lyophilized non-pyrogenic medication meant to be infused into the skin. AmBisome is its international name, whereas in India it is available by the name of Phosome.

Purpose:

• This injection is meant to cure fungal infections.
• Visceral leishmaniasis which is a parasitic disease, and cryptococcal meningitis; a fungal infection caused in the brain and the spinal cord are treated with Liposomal Amphotericin B 10mg, 25mg, 50mg Injection.
• People who are unable to get conventional amphotericin B therapy, are recommended to opt for this drug.
• Phosome slows down the growth of fungi.

 

Mechanism:

It works by binding the sterol component of the cell membrane that forms a transmembrane channel. It also helps in the binding of the cholesterol component that leads to cytotoxicity.

 

Dosage:

• As directed by your doctor/physician.
• It can be infused over a period of 2 hours for treating leishmaniasis.
• AmBisome should be infused once daily for treating meningitis.
• It should be directed to the vein only.
• If dropped in between, this injection should be restarted from the lowest dosage.

 

Side effects:

• Common side effects: headache, chills, dizziness, fever, loss of appetite, fast breathing, shaking, and fast breathing.
• Serious side effects: change in vision, dark urine, blue lips, seizures, black stools, kidney problems among others.
• There’s a rare chance of a serious allergic reaction to Phosome. If this happens, you should consult your doctor right away.
• If there’s an anaphylactic reaction to this injection, discontinue its infusion and visit your doctor.

Precautions and measures:

• If you’ve had a history of heart disease, leukocytes transfusion(white blood cells), kidney disease, or liver disease, inform your doctor before getting on the medication of Liposomal Amphotericin B 10mg, 25mg, 50mg Injection.
• Breastfeeding should not be done if you’re under this treatment.
• If your doctor recommends a special diet, follow it religiously.
• This drug is meant to be administered by a medical professional.
• It has been established that it is safe for the consumption of all individuals, but must be injected with extreme care in young ones and extra elderly people.

 

Interactions:

• Azole antifungals like Itraconazole and Ketoconazole can react with Phosome.
• Reverse action of the injection can also happen if used along with anti-cancer drugs such as nitrogen mustard or mechlorethamine.

Muscle reactants have also been known to react with Liposomal Amphotericin B 10mg, 25mg, 50mg Injection, hence should be avoided.