Details

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Mycophenolate Mofetil (Mycophenolic acid) 500mg Suspension comes under the immunosuppressant category of drugs.

It is used to suppress the harmful reaction of the immune response within the body due to autoimmune disorder or after organ transplant.

Mycophenolate mofetil aka MMF, is a semi synthetic derivative of mycophenolic acid, derived from fungus Penicillium glaucus.

Mycophenolate mofetil is hydrolyzed to mycophenolic acid, the active immunosuppressive and synthesized and administered as MMF.

Mechanism of action: MMF acts by inhibition of synthesis of purines leading to inhibition of T- and B-lymphocyte action hence lowering the immunity of the body.

It is available as Cellcept in Indian market and as Myfortic & Cellcept in the International market.

 

Uses

• Mycophenolate Mofetil (Mycophenolic acid) 500mg Suspension is prescribed in solid organ transplant patients for refractory rejection like kidney, heart,liver transplants
• It is also given in combination with prednisone in case of intolerance of cyclosporine or tacrolimus.
• Cellcept is used in reducing chronic allograft vasculopathy in cardiac transplant patients.
• It is used as a prophylaxis and treatment of both acute and chronic graft versus host(GVH) disease in hematopoietic stem cell transplant patients.
• Recently it has also been used in lupus nephritis, rheumatoid arthritis, inflammatory bowel disease, and some dermatologic disorders.

 

Dosage

• Mycophenolate Mofetil (Mycophenolic acid) 500mg Suspension comes as a powder and solvent that is reconstituted before using.
• Cellcept is an immunosuppressant, dosages are only determined by the doctor according to the pre existing medical condition , ongoing medications, any allergy and response of the body.

 

Side effects

Mycophenolate Mofetil (Mycophenolic acid) 500mg Suspension, being an immunosuppressant has following side effects:

• nausea and vomiting
• diarrhea, abdominal pain
• headache
• hypertension
• reversible myelosuppression (primarily neutropenia), so blood tests are done frequently to check blood cells count
• Hepatic toxicity
• Meningitis
• Susceptibility to immunity related infections
• In children : sore throat, fever, cold (respiratory tract infections)

 

Warning

• Myfortic is an immunosuppressant affecting the immunity of the human body so it is very necessary to monitor the immunity related infections.
• Any minor infection can cause fatal effects on the body as infection resistance of the human body is lowered.
• Contact with communicable disease infected persons or carriers must be avoided as it will transfer the infection.
• In pregnant women it causes death of the foetus or severe foetal toxicity.so it is contraindicated in pregnancy.

Any allergy or ongoing medication must be told to the doctor as this drug may aggravate or interact with that medication.