Details

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Paclitaxel Nanoparticles 100mg Injection is a Cell Cycle-Specific (CCS) anticancer drug belonging to group taxanes.

It acts on the mitosis phase of the tumor cell.

It is an albumin-bound paclitaxel nanoparticle formulation.

It is effective against a broad range of solid tumors and does not require premedication for hypersensitivity reactions unlike paclitaxel.

Mechanism of action:it acts as a mitotic spindle poison and binds to microtubules leading to tubulin polymerization. This results in inhibition of mitosis and cell division of cancer cells.

It is available as Abraxane in both International and Indian markets.

 

Uses

• Paclitaxel Nanoparticles 100mg Injection is used as first line treatment of metastatic adenocarcinoma of the pancreas in combination with gemcitabine.
• Abraxane is used as first line treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) in combination with carboplatin.
• It is used in metastatic breast cancer after failure of chemotherapy or relapse within 6 months of adjuvant therapy.
• Other indications of Abraxane are small cell lung cancer, ovarian cancer, gastroesophageal cancer, prostate cancer ,bladder cancer, AIDS-related Kaposi’s sarcoma and head and neck cancer.

 

Dosage

• Paclitaxel Nanoparticles 100mg Injection is available as single-dose vial containing white to yellow, sterile, lyophilized powder for reconstitution for intravenous use.
• Abraxane must be administered by healthcare professionals only because extravasation of this drug causes serious tissue injury.
• Follow the preparation instructions carefully for reconstitution.
• If it contacts skin wash immediately with soap and if it contacts mucus membrane wash thoroughly with water.
• Final dosages are determined by the doctor on the basis of factors such as pre existing medical condition, age, weight and ongoing medications.
• Dose is adjusted to minimise dose related side effects.

Side effects

• Headache
• Fever
• FatigueHypotension
• Severe sepsis
• Nausea and vomiting
• Diarrhea
• Mucositis
• Arrhythmias
• Hypersensitivity
• Myelosuppression mainly neutropenia
• Peripheral sensory neuropathy
• Severe sepsis
• Pneumonitis
• Infections
• Bradycardia
• Cough and dyspnea
• Hair loss
• Myelosuppression
• Elevated liver function tests
• Infections

Precautions

• Paclitaxel Nanoparticles 100mg Injection is contraindicated in patients with neutrophils count less than 1,500 cells/mm3 and patients having a history of severe hypersensitivity to paclitaxel.
• Abraxane must not be used in pregnancy as it causes serious damage to the fetus and also must not be in breastfeeding mothers.
• Careful monitoring of blood cell count , liver and heart function must be done.
• Tell the doctor about pre existing medical conditions, ongoing medications and any allergy before starting the drug.

Always tell the doctor about pregnancy or future plan of pregnancy or breastfeeding.

 

Frequently Asked Questions

1. What is Abraxane 100 mg Injection?
Abraxane 100 mg Injection contains paclitaxel nanoparticles in an albumin-bound formulation. It is an anticancer medicine used under medical supervision for the treatment of certain cancers.

2. What is Abraxane used for?
Abraxane is used in the treatment of certain cancers, including metastatic breast cancer, pancreatic cancer, and locally advanced or metastatic non-small cell lung cancer. Its use depends on the patient’s condition and the treating doctor’s assessment.

3. What is the active ingredient in Abraxane?
The active ingredient in Abraxane is paclitaxel, provided as an albumin-bound nanoparticle formulation. The product page lists the strength as 100 mg injection.

4. How is Abraxane 100 mg Injection administered?
Abraxane is administered intravenously by a qualified healthcare professional. The dosage and treatment schedule are determined by the doctor according to the patient’s medical condition and other relevant factors.

5. What are the common side effects of Abraxane?
Possible side effects include fatigue, nausea and vomiting, diarrhea, hair loss, infections, reduced blood cell counts, peripheral neuropathy, fever, and changes in liver function. Patients should report concerning or severe symptoms to their healthcare professional.