Velcade

Details

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Bortezomib 1mg, 3.5mg Injection is an Anticancer agent. It contains an antineoplastic agent, bortezomib which is a modified boronic acid. This drug belongs to the class of bisphosphonates. Velcade is the universal name of this drug, by which it is available in the medical market.

Purpose:

• Bortezomib 1mg, 3.5mg Injection is used to treat adults with cancer of the bone marrow (multiple myeloma).
• It can be prescribed for people who have received one or more prior treatments and whose cancer is still progressing.
• Hypercalcemia (high blood calcium levels)that may occur with cancer is also treated with this drug.

Dosage:

• Strictly as prescribed by your doctor.
• The dose of Velcade will be calculated from your weight and height.
• Other factors such as kidney and liver function, and response to the medication, are also taken into consideration.
• The recommended dosage for effective results is 1.3mg per square meter body surface area.

Side effects:

• Common side effects of Velcade are nausea, diarrhea, fever, lightheadedness, headache, vomiting among others.
• Serious side effects of this injection are peripheral neuropathy, hypotension, cardiac toxicity, pulmonary toxicity, posterior reversible encephalopathy syndrome, gastrointestinal toxicity, neutropenia, tumor lysis syndrome, hepatic toxicity, thrombotic microangiopathy among others.
• If any of the above-mentioned side effects persist for long, consult your doctor right away.

Precautions and measures:

• If you’ve had an allergic reaction to bisphosphonates, this medication is not for you.
• Prohibit or at the very least limit your intake of alcohol and marijuana, as it will increase your dizziness and sleepiness.
• Do not get any vaccinations or immunizations done during the tenure of this drug.
• Keep washing your hands thoroughly.
• Do not use sharp objects like nail cutters cautiously, to prevent bruising and bleeding.
• While being on this treatment, men should not plan to father a child. This drug is likely to affect sperm production and harm the unborn baby.
• Bortezomib 1mg, 3.5mg Injection is absorbed via lungs and skin and therefore should not be used by pregnant and lactating women.
• This medication is meant for single use only.
• Make sure the nib of injection doesn’t come in contact with the blood vessel.

Interaction:

• While being on the medication of Velcade, avoid consuming other bisphosphonates, and other drugs used to treat bone loss such as zoledronic acid.

Medicines that can interact with this Bortezomib 1mg, 3.5mg Injection and produce reverse results are Gentamicin, Tobramycin, Tacrolimus, Ibuprofen, and Amphotericin B.

Frequently Asked Questions

1. What is Velcade (Bortezomib) used for?

Velcade contains bortezomib, a proteasome inhibitor used in the treatment of multiple myeloma and mantle cell lymphoma in adults. Bortezomib may be used alone or as part of combination treatment depending on the patient’s diagnosis and treatment protocol.

2. How does Velcade (Bortezomib) work?

Velcade works by inhibiting the 26S proteasome, a cellular protein-degradation system. Proteasome inhibition can disrupt protein regulation and cellular processes that are important for the survival of certain cancer cells, helping to inhibit their growth and promote cell death.

3. What strengths of Velcade injection are available?

Lotus International lists Bortezomib 1 mg and 3.5 mg injections on its Velcade product page. The current U.S. Velcade prescribing information specifies a 3.5 mg single-dose vial containing lyophilized bortezomib for reconstitution. Product presentations can vary by manufacturer and market, so international buyers should confirm the required strength and packaging with Lotus International.

4. How is Velcade administered?

Velcade is administered by subcutaneous injection or intravenous injection. The recommended starting dose in the current prescribing information is 1.3 mg/m², with the treatment schedule and dose adjustments determined according to the disease, treatment combination, patient response, and clinical factors. It must not be administered by any other route, including intrathecal administration.

5. Can international buyers source Velcade from Lotus International?

International pharmaceutical importers, distributors, wholesalers, hospitals, and procurement organizations can contact Lotus International regarding Bortezomib/Velcade supply. Buyers can enquire about product availability, required quantities, packaging, documentation, and export requirements for international pharmaceutical procurement. Lotus International lists Bortezomib injection under its Anti Cancer portfolio.