Vectibix

Details

---

Purpose

Panitumumab 20mg per ml Injection in 5ml, 10ml, 20ml Vials are used for the

• treatment of wild-type KRAS called metastatic colorectal cancer.
• treatment of first-line therapy with a combination of FOLFOX.
• As treatment of monotherapy of disease progressions such as oxaliplatin, fluoropyrimidine, and irinotecan.

The medication comes under the brand name of Vectibix.

How does it work?

The medication works by inhibiting the growth of cancer cells in the host body.  the active ingredients of Vectibix injection tend to bound with the cancer cells and hence stops their further growth.

Measures and precautions

1. Panitumumab 20mg per ml Injection in 5ml, 10ml, 20ml Vials are prescribed by the doctor to treat the KRAS mutational status in colorectal cancer.
2. The recommended dose of Vectibix injection is 6mg per kg which is intravenously infused in the host body.
3. the infusion of the injection happens over 60 minutes every 14 days. The first infusion of Panitumumab 20mg per ml Injection in 5ml, 10ml, 20ml Vials is tolerated and then it is followed by subsequent doses over 30 to 60 minutes.
4. The administration of doses higher than 1000 mg is done over 90 minutes.
5. The infusion with Vectibix injection should be done under proper medical conditions. Appropriate medical resources should be present at the time of infusions.
6. Do not try to overdose on the injection as it is extremely harmful.
7. The doses of Panitumumab 20mg per ml Injection in 5ml, 10ml, 20ml Vials depends on the severity of the disease and medical response of the host.
8. When the side-effects appear as severe, the usage of this injection should be discontinued or permanently stop.
9. While administering the drug, be extra careful. Do not infuse the injection as an intravenous push or bolus. It is harmful to the host body.
10. For infusion, prepare the solution using aseptic techniques such as a low-protein binding in-line filter.
11. Avoid adding other drugs to the solution than panitumumab. It is not recommended.
12. the prepared solution should be used within 6 hours of the preparation to observe great results.

side-effects

• nausea
• vomiting
• headache
• dizziness
• tiredness
• Diarrhea
• chills
• fever
• irritation
• itching
• sores

storage

the medication infusion is stored at room temperature at a cool place.  Do not try to freeze the medication. Use within 24 hours,  if the injection is stored at 2⁰C to 8⁰C.  avoid using expired vials as they are not good for the host body.

Frequently Asked Questions

1. What is Vectibix (Panitumumab) used for?

Vectibix contains panitumumab, an epidermal growth factor receptor (EGFR) antagonist used for certain adults with metastatic colorectal cancer (mCRC). Current U.S. prescribing information includes use in combination with FOLFOX as first-line treatment for RAS wild-type mCRC and as monotherapy after progression following specific chemotherapy. It is also indicated with sotorasib for certain adults with KRAS G12C-mutated mCRC after prior chemotherapy.

2. How does Vectibix (Panitumumab) work?

Vectibix is a fully human monoclonal antibody that targets EGFR. By binding to EGFR and interfering with EGFR signaling, panitumumab can inhibit signaling pathways involved in the growth and survival of certain colorectal cancer cells. Its use requires appropriate biomarker testing because RAS mutation status is important for determining treatment eligibility.

3. What strengths of Vectibix injection are available?

Vectibix is supplied as an intravenous injection at 100 mg/5 mL and 400 mg/20 mL, with both presentations containing 20 mg/mL of panitumumab. The exact presentation, packaging, and market availability should be confirmed with Lotus International before placing an international supply order.

4. How is Vectibix administered?

Vectibix is administered by intravenous infusion. The current labeled dose for indicated metastatic colorectal cancer treatment is 6 mg/kg every 14 days. Depending on the total dose, the infusion is administered over approximately 60 or 90 minutes. Treatment should be administered and monitored by qualified healthcare professionals.

5. Can international buyers source Vectibix from Lotus International?

Lotus International supplies oncology and anticancer medicines from India to international pharmaceutical markets and accepts bulk orders. Licensed importers, pharmaceutical distributors, wholesalers, hospitals, and procurement organizations can contact Lotus International regarding Vectibix (panitumumab) supply, including product availability, quantities, packaging, documentation, and export requirements.