Taxotere

Details

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Docetaxel 20mg, 80mg, 120mg Injection is an anti cancer drug, which acts directly on the cancer cells.

It is further subgrouped as taxanes under cell cycle specific anticancer drugs.

It is derived from the European yew tree semi synthetically.

Mechanism of action: it acts by enhancing the polymerisation of tubulin, which inhibits the normal reorganisation of microtubular structure of the virus infected cell. This structure is required for interphase of the viral cell cycle and mitotic functions during M phase.inhibition of the tubular structure leads to the death of the cell.

It is available as Taxotere, both in the Indian and International market.

Uses

• Docetaxel 20mg, 80mg, 120mg Injection is prescribed in metastatic ovarian and breast cancer, where the first line of treatment is not responsive or after relapse as approved second line treatment.
• It is efficient against advanced head and neck cancer.
• It is used in small cell lung cancer.
• It is also used in esophageal adenocarcinoma.
• Docetaxel 20mg, 80mg, 120mg Injection is prescribed in pancreatic, gastric carcinomas, bladder cancer and prostate cancer.

Dosage

• Taxotere is an anti cancer drug, it’s dosage is only determined by the doctor.
• Its doses are calculated on the basis of stage of the cancer, spreading rate of cancer, Weight, pre existing medical condition, ongoing medicines and any allergy.
• It comes as anhydrous powder concentrate for solution, in 20mg, 80mg, 120mg vials which is directly used for the infusion and stored at 2^o  to 25⁰
• It is given intravenously over one hour by healthcare professionals.

Side effects

• Hypersensitivity
• Nausea and vomiting
• Fever
• Diarrhea
• Neurotoxicity
• Fluid retention
• Eye infections
• Myelosuppression mainly neutropenia

Precautions

• Before starting Taxotere, premedication with dexamethasone, diphenhydramine, and an H2 blocker is recommended to avoid hypersensitivity reactions.
• It should not be used in abnormal liver function.
• It should not be used in pregnancy as it causes damage to the foetus, always tell the doctor about pregnancy or future plan of pregnancy.
• Taxotere is contraindicated in case of Hypersensitivity to docetaxel or history of hypersensitivity and severe neutropenia (Neutrophil counts of <1500 cells/mm3 ).
• Regular liver function tests must be done.
• Alcohol content used during the infusion can affect the ability of driving or use of machines.

Review

Docetaxel 20mg, 80mg, 120mg Injection, being a taxane, is one of the most active classes of anticancer drugs and when combined with other anti cancer drugs efficacy of chemotherapy is highly increased with higher rates of remission.

Frequently Asked Questions

1. What is Taxotere (Docetaxel) used for?

Taxotere contains docetaxel, a taxane chemotherapy medicine that works by interfering with microtubules and cell division. Docetaxel is used in the treatment of several cancers, including breast cancer, non-small cell lung cancer, metastatic castration-resistant prostate cancer, gastric adenocarcinoma, and locally advanced squamous cell carcinoma of the head and neck, depending on the approved treatment regimen.

2. How does Taxotere (Docetaxel) work?

Taxotere works by stabilizing microtubules and preventing their normal breakdown, which interferes with cell division. This mechanism can inhibit the proliferation of rapidly dividing cancer cells. Docetaxel treatment should be administered and monitored by qualified oncology professionals.

3. What strengths of Taxotere injection are available?

Taxotere has been supplied as a 20 mg/mL and 80 mg/4 mL intravenous injection presentation. Other docetaxel products may have additional vial presentations, such as 160 mg/8 mL, depending on the manufacturer and market. International buyers should confirm the required strength, presentation, packaging, and availability with the supplier before placing an order.

4. How is Taxotere administered?

Taxotere is administered by intravenous infusion, generally over approximately one hour, with the treatment schedule and dose determined according to the cancer type and prescribed treatment regimen. Corticosteroid premedication is recommended for patients receiving docetaxel to help reduce certain treatment-related risks. Administration should take place in an appropriate medical facility under qualified healthcare supervision.

5. Can international buyers source Taxotere from Lotus International?

International pharmaceutical importers, distributors, wholesalers, hospitals, and procurement organizations can contact Lotus International to enquire about Taxotere (docetaxel) supply. Buyers can discuss product availability, required quantities, packaging, export documentation, and international pharmaceutical supply requirements with Lotus International.