Ristova

Ristova

Drug Name:

Rituximab 100mg, 500mg Injection

Category:

International Brand: Rituxan/Mabthera

Rituxan/Mabthera

Details

Rituximab 100mg, 500mg Injection is an Anticancer drug. It is a genetically engineered chimeric human monoclonal antibody. This injection is a colorless, sterile, clear solution that is packed in a single-use vial. Internationally it is known by the name of Rituxan and Mabthera. And in Indian pharmacies, it is available under the brand name Ristova.

Purpose:

Rituximab 100mg, 500mg Injection is used for treating patients suffering with:

  • Chronic Lymphocytic Leukaemia (CLL) individually or with other medicines of chemotherapy.
  • Non-Hodgkin’s Lymphoma (NHL) with cyclophosphamide and fludarabine.
  • Rheumatoid Arthritis (RA)
  • Granulomatosis with Polyangiitis (GPA)

Mechanism:

Rituxan injection targets the CD20 antigen available on the surface of mature-B and pre-B lymphocytes. This medication binds with CD20 and mediates B-cell lysis.

Dosage:

  • As prescribed by your physician/doctor.
  • Recommended infusion of Mabthera for effective results: Initial dosage should be of 100mg per hour to maximum of 400mg per hour.
  • Administer this dose of Ristova once a week for 4-8 doses.
  • For pediatric patients, the dosage should be 375mg once a week for 4 doses.

Side effects:

  • Progressive multifocal leukoencephalopathy
  • Bowel obstruction and perforation
  • Renal toxicity
  • Hepatitis B reactivation with fulminant hepatitis
  • Cardiovascular adverse reactions
  • Tumor lysis syndrome
  • Severe mucocutaneous reactions
  • Infusion-related reactions
  • Common side effects of Ristova are headache, fever, chills, back pain, rashes, redness at the site of injection, nausea, dizziness, tiredness among others.

Precautions and measures:

  • Inform your doctor about your medical history of lung disease, irregular heartbeat, a blood disorder, or any recent infections.
  • Prohibit the intake of alcohol and marijuana, as it will cause more sleepiness and dizziness.
  • Do not get any vaccinations or immunizations during the tenure of Ristova.
  • During pregnancy Rituximab 100mg, 500mg Injection should only be used if necessary.
  • Older people are at a greater risk of developing lung and heart problems while on this medication.
  • Store it at a cool temperature.
  • Keep it away from kids and pets.
  • The cap of the vial has rubber latex, which can lead to an allergic reaction.
  • Do not expose it to sunlight.
  • Be cautious while this injection is being injected. It should not come in contact with the blood vessel.
  • A complete blood count should be done before starting this medication.
  • Do not stop, start, increase or decrease the dosage at your own ease.
  • Do not flush the remains or pour them into a sink.

Interactions:

Some drugs that might react with Rituximab 100mg, 500mg Injection are Tofacitinib, Fingolimod, and Natalizumab.

Frequently Asked Questions

1. What is Ristova Injection?
Ristova is an anti-cancer medicine containing rituximab, a monoclonal antibody that targets the CD20 antigen on B lymphocytes. Lotus International lists Ristova in 100 mg and 500 mg injection presentations.

2. What is Ristova (Rituximab) used for?
Rituximab is used in the treatment of certain non-Hodgkin lymphomas and chronic lymphocytic leukaemia (CLL). Depending on the approved indication and treatment protocol, it is also used for certain autoimmune conditions, including rheumatoid arthritis and granulomatosis with polyangiitis.

3. How does Ristova (Rituximab) work?
Rituximab binds to the CD20 antigen found on B cells. This promotes depletion of targeted B lymphocytes, helping reduce abnormal B-cell activity in diseases for which rituximab is indicated.

4. What strengths of Ristova are available?
Ristova is available as 100 mg/10 mL and 500 mg/50 mL single-dose vials. It is supplied as a concentrate for intravenous infusion and should be prepared and administered by qualified healthcare professionals.

5. Can international buyers source Ristova from Lotus International?
Yes. Pharmaceutical importers, distributors, wholesalers, hospitals and procurement organizations can contact Lotus International regarding Ristova supply, bulk quantities, product availability, packaging and export documentation. Destination-market regulatory and cold-chain requirements should be confirmed before procurement.