Tykerb

Details

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Lapatinib ditosylate 250mg Tablets is an anticancer drug belonging to the protein kinase inhibitors group.

It is a ditosylate salt of lapatinib(orally active quinazoline).

It is used in combination with other anticancer drugs.

It is a prescription only drug.

Mechanism of action:it acts by blocking phosphorylation of the epidermal growth factor receptor (EGFR), ErbB2, and the Erk-1 and-2 and AKT kinases resulting in their inhibition leading to the decreased or no growth of the tumor. It also acts on cyclin D protein in tumor cells to stop the growth of tumors..

It is available as Tyverb & Tykerb in both International and Tykerb Indian markets.

Uses

• Lapatinib ditosylate 250mg Tablets is used in combination with capecitabine to treat metastatic breast cancer that are HER2 positive and cases of pre-treatment with anthracycline, a taxane, and trastuzumab.
• Tyverb is also used with letrozole for treating postmenopausal women with both hormone receptor and HER2 positive metastatic breast cancer indicated with hormonal therapy.
• It is also used in combination with trastuzumab in hormone-receptor-negative metastatic tumors that have progressed prior to trastuzumab or other combination chemotherapy.

Dosage

• Lapatinib ditosylate 250mg Tablets are available as oval, biconvex, orange, film-coated with GS XJG tablets.
• Tykerb should be taken one hour before or one hour after a meal once in a day.
• It is stored at room temperature away from light and moisture.
• Final dosages are determined by the doctor on the basis of factors such as medical condition, age, weight and ongoing medications.
• Dose is modified for cardiac toxicities, severe hepatic impairment, and drug interactions to minimise the complications.

Side effects

• Headache
• Fever
• Fatigue
• Hepatotoxicity
• Nausea and vomiting
• Diarrhea
• Pneumonitis
• Dyspepsia
• Rash
• Back pain
• Dry skin
• Insomnia
• Epistaxis
• QT Prolongation
• Redness & swelling of skin
• Low levels electrolytes in blood especially potassium and magnesium

Precautions

• Lapatinib ditosylate 250mg Tablets are contraindicated in case of severe allergic reactions to lapatinib.
• Tykerb causes fetal harm if used during pregnancy and not recommended in pregnancy & breastfeeding.
• It also causes adverse effects on the reproductive system.
• It causes severe hepatotoxicity so careful liver function monitoring is necessary.
• Electrolyte imbalance should also be monitored very carefully.
• Exposure to sunlight must be avoided while using this drug.
• It must be used very carefully in heart disorders, liver and kidney dysfunction.
• Tell the doctor about ongoing medications and any allergy before starting the drug.

Always tell the doctor about pregnancy or future plan of pregnancy or breastfeeding.

Frequently Asked Questions

1. What is Tykerb (Lapatinib) used for?

Tykerb contains lapatinib ditosylate, a kinase inhibitor used in combination with other anticancer medicines for certain patients with HER2-positive advanced or metastatic breast cancer. Depending on the treatment regimen and applicable regulatory approval, lapatinib may be used with capecitabine, an aromatase inhibitor such as letrozole, or trastuzumab.

2. How does Tykerb (Lapatinib) work?

Lapatinib works by inhibiting HER2 (ErbB2) and EGFR tyrosine kinase signaling, pathways that can contribute to the growth and survival of certain breast cancer cells. By blocking these signals, lapatinib helps interfere with tumor-cell proliferation.

3. What strength of Tykerb tablets is available?

Tykerb is available as 250 mg tablets. Lotus International lists Lapatinib ditosylate 250 mg tablets on its product page. International packaging and availability can vary by market, so buyers should confirm the required presentation and supply details before placing an order.

4. How is Tykerb administered?

Tykerb is an oral tablet taken once daily. It should generally be taken at least one hour before or one hour after food, and the daily dose should not be divided. The prescribed dose varies according to the combination treatment and clinical indication. Treatment should be prescribed and monitored by a qualified healthcare professional.

5. Can international buyers source Tykerb from Lotus International?

Lotus International lists Lapatinib ditosylate 250 mg tablets under its Anti Cancer medicines portfolio. International importers, pharmaceutical distributors, wholesalers, hospitals, and procurement organizations can contact Lotus International to enquire about product availability, quantities, packaging, documentation, and export supply requirements.