Details

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Lapatinib ditosylate 250mg Tablets is an anticancer drug belonging to the protein kinase inhibitors group.

It is a ditosylate salt of lapatinib(orally active quinazoline).

It is used in combination with other anticancer drugs.

It is a prescription only drug.

Mechanism of action:it acts by blocking phosphorylation of the epidermal growth factor receptor (EGFR), ErbB2, and the Erk-1 and-2 and AKT kinases resulting in their inhibition leading to the decreased or no growth of the tumor. It also acts on cyclin D protein in tumor cells to stop the growth of tumors..

It is available as Tyverb & Tykerb in both International and Tykerb Indian markets.

 

Uses

• Lapatinib ditosylate 250mg Tablets is used in combination with capecitabine to treat metastatic breast cancer that are HER2 positive and cases of pre-treatment with anthracycline, a taxane, and trastuzumab.
• Tyverb is also used with letrozole for treating postmenopausal women with both hormone receptor and HER2 positive metastatic breast cancer indicated with hormonal therapy.
• It is also used in combination with trastuzumab in hormone-receptor-negative metastatic tumors that have progressed prior to trastuzumab or other combination chemotherapy.

 

Dosage

• Lapatinib ditosylate 250mg Tablets are available as oval, biconvex, orange, film-coated with GS XJG tablets.
• Tykerb should be taken one hour before or one hour after a meal once in a day.
• It is stored at room temperature away from light and moisture.
• Final dosages are determined by the doctor on the basis of factors such as medical condition, age, weight and ongoing medications.
• Dose is modified for cardiac toxicities, severe hepatic impairment, and drug interactions to minimise the complications.

 

Side effects

• Headache
• Fever
• Fatigue
• Hepatotoxicity
• Nausea and vomiting
• Diarrhea
• Pneumonitis
• Dyspepsia
• Rash
• Back pain
• Dry skin
• Insomnia
• Epistaxis
• QT Prolongation
• Redness & swelling of skin
• Low levels electrolytes in blood especially potassium and magnesium

 

Precautions

• Lapatinib ditosylate 250mg Tablets are contraindicated in case of severe allergic reactions to lapatinib.
• Tykerb causes fetal harm if used during pregnancy and not recommended in pregnancy & breastfeeding.
• It also causes adverse effects on the reproductive system.
• It causes severe hepatotoxicity so careful liver function monitoring is necessary.
• Electrolyte imbalance should also be monitored very carefully.
• Exposure to sunlight must be avoided while using this drug.
• It must be used very carefully in heart disorders, liver and kidney dysfunction.
• Tell the doctor about ongoing medications and any allergy before starting the drug.

Always tell the doctor about pregnancy or future plan of pregnancy or breastfeeding.