Details

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Tigecycline 50mg Injection is an antibacterial belonging to the group tetracyclines.

It is a semisynthetic derivative of minocycline and has broad spectrum bacteriostatic properties.

It is the first glycylcycline available for clinical use that is effective against organisms resistant to older tetracyclines and other antibacterials.

Mechanism of action:it acts by entering the bacterial cell by both passive and active transport. Inside the cell it binds to a bacterial ribosome blocking the RNA-ribosome complex preventing the protein synthesis leading to non functional bacterial cell and death of the cell.

It is available as Tygacil in both International and Indian markets.

 

Uses

• Tigecycline 50mg Injection is used in skin related infections caused by Escherichia coli, Streptococcus anginosus group, Streptococcus pyogenes, Enterobacter cloacae, Klebsiella pneumoniae, and Bacteroides fragilis.
• It is also used in other antibiotics resistant bacterial infections of skin like Enterococcus faecalis, Staphylococcus aureus
• It is prescribed in intra-abdominal infections caused by Citrobacter freundii, Enterobacter cloacae, Escherichia coli, Klebsiella oxytoca, Klebsiella pneumoniae, Bacteroides fragilis, Bacteroides thetaiotaomicron, Bacteroides uniformis, Bacteroides vulgatus, Clostridium perfringens, and Peptostreptococcus micros.
• Tygacil is also used in bacterial pneumonia caused by Streptococcus pneumoniae (penicillin susceptible isolates), Haemophilus influenzae (beta-lactamase negative isolates), and Legionella pneumophila.

 

Dosage

• Tigecycline 50mg Injection comes as a 50 mg lyophilized powder for reconstitution in a single-dose 5 mL vial, administered intravenously by a healthcare professional.
• Tygacil is given as a 100-mg loading dose, then 50 mg every 12 hours administered intravenously over 30-60 minutes.
• Final dosages are determined by the doctor on the basis of factors such as medical condition, age, weight and ongoing medications.
• Dose is adjusted to minimise dose related side effects.

 

Side effects

• Headache
• Fever
• Fatigue
• Hepatic dysfunction
• Liver failure
• Nausea and vomiting
• Severe anaphylactoid reactions
• Pancreatitis
• Tooth discoloration if given during tooth development age
• Clostridium difficile associated diarrhea
• Photosensitivity
• Pseudotumor cerebri
• Superinfections due to overgrowth of non susceptible organisms including fungi

 

Precautions

• Tigecycline 50mg Injection is contraindicated in case of the allergy to Tigecycline.
• It is not recommended in patients below 18 years of age.
• Tygacil causes fetal harm when administered to a pregnant woman, so it is not recommended in pregnancy and breastfeeding mothers.
• It must be used carefully in liver dysfunction and intestinal perforations.
• Careful monitoring is required to prevent infections caused by non susceptible organisms including fungi.

Always tell the doctor about the pregnancy or future plan of pregnancy or breastfeeding before starting the treatment.