Details

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Lenograstim 263 mcg (33.6 MIU) Injection is a hematopoietic growth factor that induces proper growth in precursors of white blood cells in the bone marrow.

It is a glycosylated  recombinant granulocyte colony-stimulating factor(G-CSF), one of the myeloid growth factors, available for clinical use.

Initially, it was derived from human cells but now as a recombinant, it is derived from the bacterial culture of E.coli.

Mechanism of action: G-CSF is a biological molecule that acts by inducing proliferation and differentiation of precursors of the neutrophil resulting in their normal growth. It also acts by activating the phagocytic property of mature neutrophils and prolongs their survival in the circulation. It also increases their concentration of stem cells in peripheral blood.

It is available as Granocyte34 in International and as Granocyte in Indian markets.

 

Uses

• Lenograstim 263 mcg (33.6 MIU) Injection is prescribed in neutropenia in patients undergoing myelosuppressive cancer chemotherapy and patients severe with chronic neutropenia.
• Granocyte34 is used in the recovery of the patients after bone marrow transplantation and patients being treated with stem cell or bone marrow transplantation.
• It is also prescribed to the donors of stem cells.
• Granocyte is also used to prevent any bone marrow damage after radiation exposure.

 

Dosage

• Lenograstim 263 mcg (33.6 MIU) Injection comes as a white powder with clear colorless solvent for reconstitution before administration subcutaneously or intravenous infusion by healthcare professionals.
• Dosages of Lenograstim 263 mcg (33.6 MIU) Injectionare determined by the doctor according to the severity of neutropenia, weight, and response of the body to the drug.
• Granocyte is stored in the refrigerator.

 

Side effects

• Bone and muscle pain
• Allergic reactions at the site of injection like redness, itching, swelling
• Constipation, diarrhea
• Nausea, vomiting, loss of appetite
• Insomnia
• Spleen rupture
• Tiredness, feeling unwell, dizziness
• Systemic allergic reactions
• Leukocytosis
• Kidney disease
• Malignant cell growth
• Myelodysplastic syndrome
• Lung toxicity

 

Precautions

• Do not shake the vial and if the liquid is foamy or discolored discard it.
• Granocyte can cause allergic reactions, inform the doctor immediately.
• It must not be used in myeloid malignancy patients and concurrently with cytotoxic chemotherapy and pregnancy.
• Careful monitoring of patients is required.
• Tell the doctor about any pre-existing allergy especially if it is due to latex, pre-existing medical condition and ongoing medication.
• Always tell the doctor about pregnancy, future plan of pregnancy, and breastfeeding before starting the treatment.

Inform the dentist before any dental procedure about the drug.