Ristova

Drug Name:

Rituximab 100mg, 500mg Injection

Category:

International Brand: Rituxan/Mabthera

Rituxan/Mabthera

Details

Rituximab 100mg, 500mg Injection is an Anticancer drug. It is a genetically engineered chimeric human monoclonal antibody. This injection is a colorless, sterile, clear solution that is packed in a single-use vial. Internationally it is known by the name of Rituxan and Mabthera. And in Indian pharmacies, it is available under the brand name Ristova.

Purpose:

Rituximab 100mg, 500mg Injection is used for treating patients suffering with:

  • Chronic Lymphocytic Leukaemia (CLL) individually or with other medicines of chemotherapy.
  • Non-Hodgkin’s Lymphoma (NHL) with cyclophosphamide and fludarabine.
  • Rheumatoid Arthritis (RA)
  • Granulomatosis with Polyangiitis (GPA)

 

Mechanism:

Rituxan injection targets the CD20 antigen available on the surface of mature-B and pre-B lymphocytes. This medication binds with CD20 and mediates B-cell lysis.

 

Dosage:

  • As prescribed by your physician/doctor.
  • Recommended infusion of Mabthera for effective results: Initial dosage should be of 100mg per hour to maximum of 400mg per hour.
  • Administer this dose of Ristova once a week for 4-8 doses.
  • For pediatric patients, the dosage should be 375mg once a week for 4 doses.

 

Side effects:

  • Progressive multifocal leukoencephalopathy
  • Bowel obstruction and perforation
  • Renal toxicity
  • Hepatitis B reactivation with fulminant hepatitis
  • Cardiovascular adverse reactions
  • Tumor lysis syndrome
  • Severe mucocutaneous reactions
  • Infusion-related reactions
  • Common side effects of Ristova are headache, fever, chills, back pain, rashes, redness at the site of injection, nausea, dizziness, tiredness among others.

 

Precautions and measures:

  • Inform your doctor about your medical history of lung disease, irregular heartbeat, a blood disorder, or any recent infections.
  • Prohibit the intake of alcohol and marijuana, as it will cause more sleepiness and dizziness.
  • Do not get any vaccinations or immunizations during the tenure of Ristova.
  • During pregnancy Rituximab 100mg, 500mg Injection should only be used if necessary.
  • Older people are at a greater risk of developing lung and heart problems while on this medication.
  • Store it at a cool temperature.
  • Keep it away from kids and pets.
  • The cap of the vial has rubber latex, which can lead to an allergic reaction.
  • Do not expose it to sunlight.
  • Be cautious while this injection is being injected. It should not come in contact with the blood vessel.
  • A complete blood count should be done before starting this medication.
  • Do not stop, start, increase or decrease the dosage at your own ease.
  • Do not flush the remains or pour them into a sink.

 

Interactions:

Some drugs that might react with Rituximab 100mg, 500mg Injection are Tofacitinib, Fingolimod, and Natalizumab.